Valid 11/2002 - 01/2003

Sigma Chemical Co.
P.O. Box 14508
St. Louis, MO 63178 USA
Tel: 314-771-5765





             M A T E R I A L  S A F E T Y  D A T A  S H E E T
             
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
    CATALOG #:            I158
    NAME:                 IVERMECTIN
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
    CAS #: 70288-86-7
    EC NO:  274-536-0
  SYNONYMS
    HYVERMECTIN * IVERMECTIN (9CI) * MK-0933 * MK 933 *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
  LABEL PRECAUTIONARY STATEMENTS
    HIGHLY TOXIC (USA)
    TOXIC (EU)
    TOXIC IF SWALLOWED.
    IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
    IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
    WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
    PROTECTION.
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
    IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
    CALL A PHYSICIAN IMMEDIATELY.
    IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
    RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
    IN CASE OF SKIN CONTACT, FLUSH WITH COPIOUS AMOUNTS OF WATER
    FOR AT LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND
    SHOES. CALL A PHYSICIAN.
    IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS OF WATER
    FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY SEPARATING
    THE EYELIDS WITH FINGERS. CALL A PHYSICIAN.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
  EXTINGUISHING MEDIA
    WATER SPRAY.
    CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
  SPECIAL FIREFIGHTING PROCEDURES
    WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
    PREVENT CONTACT WITH SKIN AND EYES.
  UNUSUAL FIRE AND EXPLOSIONS HAZARDS
    EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
    WEAR SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY
    RUBBER GLOVES.
    SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL.
    AVOID RAISING DUST.
    VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
    EVACUATE AREA.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
    REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
    SAFETY SHOWER AND EYE BATH.
    USE ONLY IN A CHEMICAL FUME HOOD.
    WASH CONTAMINATED CLOTHING BEFORE REUSE.
    WASH THOROUGHLY AFTER HANDLING.
    DO NOT BREATHE DUST.
    DO NOT GET IN EYES, ON SKIN, ON CLOTHING.
    AVOID PROLONGED OR REPEATED EXPOSURE.
    NIOSH/MSHA-APPROVED RESPIRATOR.
    COMPATIBLE CHEMICAL-RESISTANT GLOVES.
    CHEMICAL SAFETY GOGGLES.
    KEEP TIGHTLY CLOSED.
    REFRIGERATE.
    STORE IN THE DARK.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
  APPEARANCE AND ODOR
    SOLID.
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
  STABILITY
    STABLE.
  INCOMPATIBILITIES
    SENSITIVE TO LIGHT
    STRONG OXIDIZING AGENTS
  HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
    CARBON MONOXIDE, CARBON DIOXIDE
  HAZARDOUS POLYMERIZATION
    WILL NOT OCCUR.
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
  ACUTE EFFECTS
    MAY CAUSE SKIN IRRITATION.
    MAY CAUSE EYE IRRITATION.
    MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRANES AND UPPER
    RESPIRATORY TRACT.
    MAY BE FATAL IF INHALED, SWALLOWED, OR ABSORBED THROUGH SKIN.
    EXPOSURE CAN CAUSE:
    NAUSEA, DIZZINESS AND HEADACHE
    TO THE BEST OF OUR KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND
    TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.
  RTECS #: IH7891500
    22,23-DIHYDROAVERMECTIN B1
  TOXICITY DATA
    ORL-RAT LD50:10 MG/KG                         USXXAM #5006545
    IPR-RAT LD50:55 MG/KG                         JJTOEX 12,227,1999
    ORL-MUS LD50:25 MG/KG                         JJTOEX 12,227,1999
    IPR-MUS LD50:30 MG/KG                         JJTOEX 12,227,1999
    ORL-DOG LD50:80 MG/KG                         JJTOEX 12,227,1999
    ORL-MKY LD50:>24 MG/KG                        JJTOEX 12,227,1999
  TARGET ORGAN DATA
    PERIPHERAL NERVE AND SENSATION (PARESTHESIA)
    MATERNAL EFFECTS (PARTURITION)
    EFFECTS ON NEWBORN (WEANING OR LACTATION INDEX)
    EFFECTS ON NEWBORN (GROWTH STATISTICS)
    EFFECTS ON NEWBORN (BEHAVIORAL)
    EFFECTS ON NEWBORN (OTHER POSTNATAL MEASURES OR EFFECTS)
    EFFECTS ON NEWBORN (DELAYED EFFECTS)
    ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
    (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
    COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
    DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
    DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A
    CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
    OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
    CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
  EUROPEAN INFORMATION
    TOXIC
    R 25
    TOXIC IF SWALLOWED.
    S 45
    IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
    IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
    S 36/37/39
    WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
    PROTECTION.
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
    THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
    BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
    FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
    OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
    PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
    COPYRIGHT 2001 SIGMA-ALDRICH CO.
    LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY